MusicSarreV3, Main, Exploration, bibRecord, 000B94

A multicentre European registry of intraluminal coronary beta brachytherapy

Identifieur interne : 000B94 ( Main/Exploration ); précédent : 000B93; suivant : 000B95

A multicentre European registry of intraluminal coronary beta brachytherapy

Auteurs : P. Urban [Suisse] ; P. Serruys [Suisse] ; D. Baumgart [Suisse] ; A. Colombo [Suisse] ; S. Silber [Suisse] ; E. Eeckhout [Suisse] ; A. Gershlick [Suisse] ; K. Wegscheider [Suisse] ; L. Verhees [Suisse] ; R. Bonan [Suisse]

Source :

European Heart Journal [ 0195-668X ] ; 2003-04-01.

RBID : ISTEX:03098FC5BD72B91348AF183235FB179513104B61

Descripteurs français

Wicri :
- topic : Irradiation.

English descriptors

Abstract

Aims To assess the feasibility, safety and effectiveness of intravascular brachytherapy (VBT) in routine clinical practice. Methods and results Between April 1999 and September 2000, 1098 consecutive patients treated in 46 European centres by intraluminal irradiation using a Sr/Y90source train (BetaCath™, Novoste, GA) were included in a registry, and follow-up data were obtained for 98.8% of them after 6.3±2.4 months. Eight hundred and forty (76.5%) patients were males, and mean age was 62.0±10.2 years. Two hundred and seventy-one (26.9%) had unstable angina, and 256 (23.5%) were diabetics. Nine hundred and thirteen lesions (77.7%) were the result of in-stent restenosis, 208 (17.7%) were de novo lesions and 48 (4.1%) non-stented restenotic lesions. Mean estimated reference diameter was 3.2±0.5mm and mean estimated lesion length was 19.0±11.8mm. The prescribed radiation dose was 18.8±3.2Gy. Multivessel irradiation was done in 6.2% of cases, and a new stent was implanted in 29.6% of cases. Most patients received 6 or 12 months of combined aspirin and thienopyridin treatment after the procedure. Technical success was obtained in 95.9% of treated lesions, and the in-hospital major adverse cardiac event (MACE) rate was 1.8%. At follow-up, the MACE rate was 18.7% (1.9% deaths from any cause, 2.6% AMI, 13.3% TVR by PCI and 3.3% TVR by CABG). Conclusion The major current application of VBT is the treatment of in-stent restenosis. The good results of VBT observed in recent randomized controlled trials can be reproduced in clinical practice.

Url:

https://api.istex.fr/document/03098FC5BD72B91348AF183235FB179513104B61/fulltext/pdf

DOI: 10.1016/S0195-668X(02)00617-6

Affiliations:

Suisse

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Irradiation</term>
<term>Restenosis</term>
<term>Stent</term>
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<keywords scheme="Teeft" xml:lang="en"><term>American college</term>
<term>Angiographic</term>
<term>Angiographic data</term>
<term>Angiographic restenosis</term>
<term>Angioplasty</term>
<term>Antiplatelet</term>
<term>Antiplatelet therapy</term>
<term>Antiplatelet treatment</term>
<term>Balloon angioplasty</term>
<term>Beta</term>
<term>Beta brachytherapy</term>
<term>Beta brachytherapy table</term>
<term>Brachytherapy</term>
<term>Cardiac</term>
<term>Cardiac death</term>
<term>Cardiac event</term>
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<term>Centre</term>
<term>Clinical trials</term>
<term>Coll</term>
<term>Coll cardiol</term>
<term>Consecutive patients</term>
<term>Coronary</term>
<term>Coronary angioplasty</term>
<term>Coronary artery</term>
<term>Coronary artery disease</term>
<term>Coronary restenosis</term>
<term>Coronary stent placement</term>
<term>Coronary stenting</term>
<term>Data collection</term>
<term>Delivery catheter</term>
<term>Elective stenting</term>
<term>Elsevier science</term>
<term>Engl</term>
<term>European society</term>
<term>Good results</term>
<term>Implantation</term>
<term>Individual patients</term>
<term>Interventional cardiology session</term>
<term>Intracoronary</term>
<term>Intracoronary radiation therapy</term>
<term>Intravascular brachytherapy</term>
<term>Late target vessel occlusion</term>
<term>Late thrombosis</term>
<term>Late thrombotic complications</term>
<term>Late vessel occlusion</term>
<term>Lesion</term>
<term>Lesion length</term>
<term>Mace</term>
<term>Mace rate</term>
<term>Mace rates</term>
<term>Multivariate</term>
<term>Multivariate predictors</term>
<term>Multivessel disease</term>
<term>Myocardial infarction</term>
<term>Occlusion</term>
<term>Odds ratio</term>
<term>Particular interest</term>
<term>Patient recruitment</term>
<term>Predictive factors</term>
<term>Predictor</term>
<term>Present registry</term>
<term>Present series</term>
<term>Randomized</term>
<term>Randomized comparison</term>
<term>Randomized trials</term>
<term>Real world</term>
<term>Reference diameter</term>
<term>Restenosis</term>
<term>Restenosis trial</term>
<term>Restenotic lesions</term>
<term>Revascularization</term>
<term>Serruys</term>
<term>Significant decrease</term>
<term>Source train</term>
<term>Source traina</term>
<term>Source trains</term>
<term>Stent</term>
<term>Stent implantation</term>
<term>Stenting</term>
<term>Target lesion</term>
<term>Target vessel</term>
<term>Target vessel revascularization</term>
<term>Thrombotic</term>
<term>Treatment failure</term>
<term>Unstable angina</term>
<term>Waksman</term>
<term>Washington radiation</term>
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<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Irradiation</term>
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<front><div type="abstract" xml:lang="en">Aims To assess the feasibility, safety and effectiveness of intravascular brachytherapy (VBT) in routine clinical practice. Methods and results Between April 1999 and September 2000, 1098 consecutive patients treated in 46 European centres by intraluminal irradiation using a Sr/Y90source train (BetaCath™, Novoste, GA) were included in a registry, and follow-up data were obtained for 98.8% of them after 6.3±2.4 months. Eight hundred and forty (76.5%) patients were males, and mean age was 62.0±10.2 years. Two hundred and seventy-one (26.9%) had unstable angina, and 256 (23.5%) were diabetics. Nine hundred and thirteen lesions (77.7%) were the result of in-stent restenosis, 208 (17.7%) were de novo lesions and 48 (4.1%) non-stented restenotic lesions. Mean estimated reference diameter was 3.2±0.5mm and mean estimated lesion length was 19.0±11.8mm. The prescribed radiation dose was 18.8±3.2Gy. Multivessel irradiation was done in 6.2% of cases, and a new stent was implanted in 29.6% of cases. Most patients received 6 or 12 months of combined aspirin and thienopyridin treatment after the procedure. Technical success was obtained in 95.9% of treated lesions, and the in-hospital major adverse cardiac event (MACE) rate was 1.8%. At follow-up, the MACE rate was 18.7% (1.9% deaths from any cause, 2.6% AMI, 13.3% TVR by PCI and 3.3% TVR by CABG). Conclusion The major current application of VBT is the treatment of in-stent restenosis. The good results of VBT observed in recent randomized controlled trials can be reproduced in clinical practice.</div>
</front>
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<name sortKey="Silber, S" sort="Silber, S" uniqKey="Silber S" first="S." last="Silber">S. Silber</name>
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A multicentre European registry of intraluminal coronary beta brachytherapy

A multicentre European registry of intraluminal coronary beta brachytherapy

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri